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309 METTL3 also represses autophagy in ischemic heart disease by methylating TFEB mRNA, decreasing its stability and nuclear translocation, thereby impairing lysosomal biogenesis and exacerbating myocardial injury during hypoxiareoxygenation

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Sulfasalazine-mediated GSH depletion inhibits sarcoma cell growth both in vitro and in preclinical mouse models [202]

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These results typically appear as patients begin to lose weight over time